Troponin T release after heart transplantation.
نویسندگان
چکیده
منابع مشابه
Troponin T release after heart transplantation.
BACKGROUND For the diagnosis of myocardial cell damage the measurement of the serum concentrations of myofibrillar antigens has several potential advantages over the assessment of traditional serological markers. These include the expression of myofibrillar antigens as cardiospecific isoforms and their high intracellular concentrations. Recently a sensitive and specific enzyme immunoassay for c...
متن کاملPredictive value of high-sensitive troponin T to rule out acute rejection after heart transplantation.
time after HT (R = -0.49; P = .0001). The ROC curve of hs-TnT for detecting AR was 0.682 (95%CI, 0.54-0.81; P = .01). A hs-TnT concentration < 17 ng/L ruled out AR with a sensitivity and a negative predictive value of 100%, but a specificity of 13% (Table 2); there were 29 true negatives for AR with hs-TnT < 17 ng/L. In a mixed-effects logistic regression model, the hs-TnT values were log trans...
متن کاملElevated serum concentrations of cardiac troponin T in acute allograft rejection after human heart transplantation.
OBJECTIVES This study evaluates the concept and diagnostic efficacy of using serum troponin T for the detection of cardiac graft rejection. BACKGROUND Cardiac troponin T is a cardiospecific myofibrillar protein, which is only detectable in the circulation after cardiac myocyte damage. It might be expected to be released during acute heart allograft rejection, allowing noninvasive rejection di...
متن کاملTroponin T release in hemodialysis patients.
To the Editor: We read with interest the recent article by Diris et al1 investigating the reason for elevated serum concentrations of cardiac troponin T (cTnT) in hemodialysis patients. The authors found variable amounts of different cTnT fragments in the blood of hemodialysis patients, ranging in size from 8 to 25 kDa. In contrast, intact cTnT (39 kDa) was found only in the cTnT-spiked, pooled...
متن کاملDonor Troponin and Survival After Cardiac Transplantation
Heart transplantation is one of the greatest achievements in modern medicine. Patients with advanced heart failure in whom survival is measured in weeks and months are offered the potential for survival of ≥10 years with excellent quality of life. Unfortunately, during the past 2 decades the number of heart transplants performed in the United States has remained static, between 2000 and 2400 an...
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ژورنال
عنوان ژورنال: Heart
سال: 1993
ISSN: 1355-6037
DOI: 10.1136/hrt.69.5.395